Chemistry & Chemical Engineering Research Center of Iran

Modular Green One-pot Synthesis of Ethyl Oxalyl Functionalized Dithiocarbamate

Document Type : Research Articles

Abstract
Dithiocarbamates and their derivatives play a crucial role in medicinal chemistry and agriculture, especially when combined with novel systemic fungicides to enhance their effectiveness. To address the environmental concerns associated with traditional toxic organic solvents, the use of environmentally friendly reaction media, such as deep eutectic solvents and ethyl acetate, has emerged as a promising alternative. This report presents a one-pot synthesis of novel dialkylthiocarbamate derivatives using ethyl acetate as a green solvent. The reaction exhibits excellent yields, short reaction times and eliminates the need for harmful solvents and laborious work-up procedures.

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Articles in Press, Accepted Manuscript
Available Online from 11 August 2025